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2 edition of Application of sheep lymphatic dynamics to monitor immune responses in periodontal tissues found in the catalog.

Application of sheep lymphatic dynamics to monitor immune responses in periodontal tissues

Binh Au

Application of sheep lymphatic dynamics to monitor immune responses in periodontal tissues

by Binh Au

  • 62 Want to read
  • 7 Currently reading

Published .
Written in English

Edition Notes

Thesis (Ph.D.)--University of Toronto, 2002.

Statementby Binh Au.
The Physical Object
Paginationxiv, 154 leaves :
Number of Pages154
ID Numbers
Open LibraryOL21163268M
ISBN 100612746283

The lymphatic vessels protect against periodontitis in mice, probably by clearing bacteria and bacterial products and by promoting humoral immune responses. Down-regulation of CCL21, a ligand important for dendritic cell migration, has been demonstrated in lymphatics from patients with periodontitis. Introduction. Lymphoid tissue covers all of the various tissues that are important in mounting an immune response. This includes discrete organs such as the spleen, thymus and lymph nodes, as well as more diffuse aggregations of lymphocytes.

The peritoneal cell populations (PCP) are thought to play a crucial role during the early immune response in Fasciola hepatica infection while newly excysted juveniles (NEJ) are migrating in the peritoneal cavity (PC) towards the liver. In this study, we aimed to determine the immunophenotypes of the PCP and to analyse the dynamics of the recruitment of the PCP during the early and late stage.   Sheep's immune system anything but sheepish and to see if an autoimmune response is the cause of death for the sheep with the high antibody levels.

  Several groups have expanded organoid culture into immune tissues from mice that successfully support humoral responses [,,,,,,]. Ankur Singh and colleagues extended organoid systems to immune tissues in a fully animal-independent way [, ].   1. LYMPHOID TISSUES Maj Dr Rishi Pokhrel MBBS, MD Lecturer, NAIHS FAIMER Fellow, USA 2. 2 Lymphatic System-Organs 3. Lymphatic System • Not a primary tissue type but a variety of connective tissue. • Consists of: lymph - network of vessels - lymph nodes and nodules, MALT - tonsils - spleen - thymus gland - bone marrow 4.

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Application of sheep lymphatic dynamics to monitor immune responses in periodontal tissues by Binh Au Download PDF EPUB FB2

An acute pain stimulus resulted in elevated lymph flow and output of cells from the popliteal lymph node of the sheep in the first 15 min after the stress. Efferent lymph flow increased by an average of 93% above the mean resting flow and cell output rose by an average of % during this period, but by 30 min after the stress, values for both Cited by: 8.

Focusing on periodontal tissues, in this article we summarize the knowledge in this field by giving an overview of the role of lymphatic vessels in tissue fluid homeostasis and also their functions as part of the body`s immune system.

The lymphangiogenic responses in Cited by: 5. Figure 1. Anatomy of the Lymphatic System. Lymphatic vessels in the arms and legs convey lymph to the larger lymphatic vessels in the torso. A major distinction between the lymphatic and cardiovascular systems in humans is that lymph is not actively pumped by the heart, but is forced through the vessels by the movements of the body, the contraction of skeletal muscles during body movements.

in gingiva during periodontal disease development and up-regulation of VEGF-C in recruited immune cells is likely important for the growth of lymphatic vessels. Moreover, gingival lymphatic vessels protect against P. gingivalis induced periodontitis, probably by enhancing clearance of bacterial products and promoting humoral immune : Lilian E.

Mkonyi. Sheep are not only a major livestock species globally, they are also an important large animal model for biomedical research and have contributed to our understanding of the ontogeny and architecture of the mammalian immune system. In this study, we applied immunohistochemistry and multicolor immunofluorescence in fixed and paraffin-embedded lymph nodes to phenotype the key Cited by: 1.

A number of animal model systems for periodontitis have been utilized in the study of the host–bacteria inter-relationships: (i) rodent models of periodontal disease have been useful in developing an understanding of the characteristics of adaptive immune response mechanisms in periodontitis; (ii) the canine model has been used to focus on.

Mycophenolic acid (MPA) is applied in immunosuppressive therapy after organ transplantation. As a common contaminant in silage, this substance is also frequently fed to sheep unintentionally.

In this study, the effect of MPA on the immune system of sheep was examined. Four groups of 9 sheep each were fed 0, or 5 mg of MPA per kg body weight per day for 6 weeks.

Lymph Nodes. The lymph nodes are extremely numerous and disseminated all over the body. They mea-sure 1–25 mm in diameter and play a very important and dynamic role in the initial or in-ductive states of the immune response. Anatomical Organization The lymph nodes are circumscribed by a connective tissue capsule.

Sheep Lymph Node. ATM. Sheep Mammary. ATN. Sheep Nerve. ATP. Sheep Pancreas. ATR. Sheep Reproductive Organs. ATSM. Sheep Skeletal Muscle. ATS. Sheep Skin. ATSP. Sheep Spleen. ATT.

Sheep Thyroids. To specify gender, include the letter M or F after the catalog number, preceded by a hyphen. Otherwise it will be.

A problem with studying the local immune response is the in vivo accessibility of the abomasum for experimental sampling. The development of the techniqueto cannulatethe gastric lymph duct which contains efferent lymph from the ovine stomachs made it possible to monitor local immune responses to abomasal nematodes (Smith, ).

Gill et al. The lymphatic system branches throughout the body to transport bodily fluid and plays a key immune-response role.

Optical coherence tomography (OCT) is an emerging technique for the noninvasive. Innate responses are generated at the periphery of sites of microbial penetration, whereas adaptive immune responses are generated at secondary lymphoid tissues, such as lymph.

infected sheep. The immune markers present in the blood and draining lymph nodes were monitored at the time of sampling; additionally, the immune responses in mononuclear cells ex vivo upon stimulation with M.

avium subsp. paratuberculosis antigen were assessed. The objective was to achieve a better understanding of the CMI responses across the. Troy D. Randall, in Advances in Immunology, Lymphatics and DC migration.

BALT areas have lymphatic vessels that are identified using the antibodies LyVE1 in mice (Carragher et al., ) or M2A in humans (Rangel-Moreno et al., ).Lymphatics are observed surrounding the B cell follicle and in the T cell area (Carragher et al., ; Kocks et al., ; Rangel-Moreno et al., ).

Function. The lymphatic system is nearly ubiquitous in the human body, present in all tissues except the epidermis, cartilage, eye lens, cornea, retina, and bone marrow [1, 2].The main functions of the lymphatic system include fluid homeostasis and interstitial fluid drainage, immune cell surveillance and trafficking, and lipid absorption [1, 3–6].

takes place. Secondary lymphoid tissues are primarily responsible for the coordination of immune responses by spatially organizing the interaction of immune effector cells;lymphoid tissues functionally equivalent tosecondary lymphoid organs often emerge under inflammatory condi-tions and are then termed tertiary lymphoid tissues [22].

The immune system is the complex collection of cells and organs that destroys or neutralizes pathogens that would otherwise cause disease or death. The lymphatic system, for most people, is associated with the immune system to such a degree that the two systems are virtually indistinguishable.

The study also touches on autoimmunity, when the body exhibits such a strong immune response that it attacks its own tissues, suggesting that autoimmunity, seen in such human diseases as lupus and. Abstract. Primary adaptive immune responses are initiated in secondary lymphoid organs, such as spleen, lymph nodes, and Peyer’s patches.

These lymphoid organs recruit naive lymphocytes 1 as well as activated antigen-presenting cells (APCs) 2, and facilitate lymphocyte activation, expansion, and example, infection of the lung with influenza virus leads to activation of.

Lymph nodes. Slides 37 and These lymphoid organs are interposed along lymphatic vessels and serve as the site where antigen is processed and presented to helper T cells. Helper T cells in turn become activated, divide and secrete cytokines that amplify the immune response. What are Secondary lymphatic organs?

Secondary lymphoid tissues are arranged as a series of filters monitoring the contents of the extracellular fluids, i.e. lymph, tissue fluid and lymphoid tissue filtering each of these fluids is arranged in different ways. Secondary lymphoid tissues are also where lymphocytes are activated.

These include: lymph nodes, tonsils, spleen, Peyer's.Lymphoid tissue has several different structural organizations related to its particular function in the immune response. The most highly organized lymphoid tissues are in the thymus and lymph nodes, which are well-defined encapsulated organs with easily identifiable architectures.

In the spleen (a soft, purplish organ lying high in the abdomen), the lymphoid tissue is a cylinder of loosely.Lymph nodes contain a hilum beneath the capsule, which brings blood supply to the tissues of the lymph node. Antigen presentation by dendritic cells occurs in the lymph nodes, which triggers an adaptive immune response.

Lymphadenopathy, the swelling of the lymph nodes, can indicate the presence of an infection or cancer.